Cystathionine beta-synthase

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This is a default text for your page Cystathionine beta-synthase. Click above on edit this page to modify. Be careful with the < and > signs.

You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.

Function

Cystathionine β-synthase (CBS) catalyzes the interconversion of cysteine and homocysteine. In bacterial systems CBS catalyzes the transfer of thiol from cysteine to homocysteine and in mammalian systems from homocysteine to cysteine.

Disease

Relevance

Structural highlights

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Human cystathionine β-synthase complex with heme, PLP and SAM (PDB id 4pcu)

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ReferencesReferences

  1. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

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Michal Harel