3soc

Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolinCrystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin

Structural highlights

3soc is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	3q4t
Gene:	ACVR2, ACVR2A (HUMAN)
Activity:	Receptor protein serine/threonine kinase, with EC number 2.7.11.30
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[AVR2A_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

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OCA