Siroheme synthase

Function Siroheme synthase (CysG) catalyzes the reduction of sulfite to sulfide or nitrite to ammonia. CysG substrate is a tetrapyrrole. Structural highlights The tetrapyrrole in siroheme is heavily negatively charged because of the 8 acetyl and propionyl carboxylates at the corners of the siroheme and it interacts with residues of subunit #1 and subunit #2. Seven of these residues are positively charged Arg and Lys residues.

spinqualitylabelsall models Salmonella typhimurium siroheme synthase complex withCo-sirohydrochlorin, SAH and Cl- ion (PDB code 6p5z) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Siroheme synthase 3D structuresSiroheme synthase 3D structures

Updated on 28-June-2022

• • 1pjq – StCysG + SAH – Salmonella typhimurium
    
  • 1pjt, 6p7c, 6p7d, 6pqz, 6pr0, 6pr1, 6pr2, 6pr3, 6pr4, 6ulu – StCysG (mutant) + SAH
    
  • 6p5z – StCysG + SAH + Co-sirohydrochlorin
    
  • 1pjs – StCysG + SAH + NAD
    
  • 6p5x – StCysG (mutant) + SAH + substrate
    
  • 6veb – StCysG (mutant) + SAH + NAD + pecorrin