1f45
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HUMAN INTERLEUKIN-12
OverviewOverview
Human interleukin-12 (IL-12, p70) is an early pro-inflammatory cytokine, comprising two disulfide-linked subunits, p35 and p40. We solved the, crystal structures of monomeric human p40 at 2.5 A and the human p70, complex at 2.8 A resolution, which reveals that IL-12 is similar to class, 1 cytokine-receptor complexes. They also include the first description of, an N-terminal immunoglobulin-like domain, found on the p40 subunit., Several charged residues from p35 and p40 intercalate to form a unique, interlocking topography, shown by mutagenesis to be critical for p70, formation. A central arginine residue from p35 projects into a deep pocket, on p40, which may be an ideal target for a small molecule antagonist of, IL-12 formation.
DiseaseDisease
Known diseases associated with this structure: Asthma, susceptibility to OMIM:[161561], BCG and salmonella infection, disseminated OMIM:[161561], Psoriasis, susceptibility to OMIM:[161561]
About this StructureAbout this Structure
1F45 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12., Yoon C, Johnston SC, Tang J, Stahl M, Tobin JF, Somers WS, EMBO J. 2000 Jul 17;19(14):3530-41. PMID:10899108
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