1euj
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A NOVEL ANTI-TUMOR CYTOKINE CONTAINS A RNA-BINDING MOTIF PRESENT IN AMINOACYL-TRNA SYNTHETASES
OverviewOverview
Endothelial monocyte-activating polypeptide II (EMAP II) is a novel, pro-apoptotic cytokine that shares sequence homology with the C-terminal, regions of several tRNA synthetases. Pro-EMAP II, the precursor of EMAP, II, is associated with the multi-tRNA synthetase complex and facilitates, aminoacylation activity. The structure of human EMAP II, solved at 1.8 A, resolution, revealed the oligomer-binding fold for binding different tRNAs, and a domain that is structurally homologous to other chemokines. The, similar structures to the RNA binding motif of EMAP II was previously, observed in the anticodon binding domain of yeast Asp-tRNA synthetase, (AspRSSC) and the B2 domain of Thermus thermophilus Phe-tRNA synthetase., The RNA binding pattern of EMAP II is likely to be nonspecific, in, contrast to the AspRSSC. The peptide sequence that is responsible for, cytokine activity is located, for the most part, in the beta1 strand. It, is divided into two regions by a neighboring loop.
About this StructureAbout this Structure
1EUJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases., Kim Y, Shin J, Li R, Cheong C, Kim K, Kim S, J Biol Chem. 2000 Sep 1;275(35):27062-8. PMID:10852899
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