2xrf
Crystal structure of human uridine phosphorylase 2Crystal structure of human uridine phosphorylase 2
Structural highlights
Function[UPP2_HUMAN] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
| ||||||||||||||||||
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Human
- Large Structures
- Uridine phosphorylase
- Arrowsmith, C H
- Berg, S Van Der
- Berglund, H
- Bountra, C
- Collins, R
- Edwards, A M
- Flodin, S
- Flores, A
- Graslund, S
- Hammarstrom, M
- Johansson, I
- Karlberg, T
- Kol, S
- Kotenyova, T
- Kouznetsova, E
- Moche, M
- Nordlund, P
- Nyman, T
- Persson, C
- Schuler, H
- Schutz, P
- Siponen, M I
- Thorsell, A G
- Tresaugues, L
- Wahlberg, E
- Weigelt, J
- Welin, M
- Transferase