1e31

OverviewOverview

Survivin is a mitotic spindle-associated protein involved in linking, mitotic spindle function to activation of apoptosis in mammalian cells., The structure of the full-length human survivin has been determined by, X-ray crystallography to 2.7 A. Strikingly, the structure forms a very, unusual bow tie-shaped dimer. It does not dimerize through a C-terminal, coiled-coil, contrary to sequence analysis prediction. The C-terminal, helices contain hydrophobic clusters with the potential for, protein-protein interactions. The unusual shape and dimensions of survivin, suggest it serves an adaptor function through its alpha-helical, extensions.

About this StructureAbout this Structure

1E31 is a Single protein structure of sequence from Homo sapiens with ZN and CO as ligands. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions., Chantalat L, Skoufias DA, Kleman JP, Jung B, Dideberg O, Margolis RL, Mol Cell. 2000 Jul;6(1):183-9. PMID:10949039

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