Ribozyme

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Ribozyme (RZ) is an RNA molecule which catalyzes a chemical reaction[1].

  • Glucosamine-6-phosphate activated RZ (glmS RZ) is a RZ and a riboswitch which regulates genes in response to metabolites.
  • Leadzyme is a small, artificially-made RZ which can cleave RNA in the presence of lead. For more details on leadzyme see Student Projects for UMass Chemistry 423 Spring 2012-10.
  • Hairpin RZ and hammerhead RZ are named based on their shape[2].
  • Group I intron catalyzes its own selfish splicing[3].
  • Comparative genomic analysis revealed Twister, Twister sister, Hatchet, and Pistol [4][5].


Articles in Proteopedia concerning ribozymes include:


To view automatically PDB-IDs concerning ribozymes, see:


Hammerhead ribozyme, (PDB-ID 379d)

Drag the structure with the mouse to rotate

3D Structures of Ribozymes3D Structures of Ribozymes

Ribozyme 3D structures

ReferencesReferences

  1. Tang J, Breaker RR. Rational design of allosteric ribozymes. Chem Biol. 1997 Jun;4(6):453-9. PMID:9224568
  2. Amarzguioui M, Prydz H. Hammerhead ribozyme design and application. Cell Mol Life Sci. 1998 Nov;54(11):1175-202. PMID:9849614 doi:http://dx.doi.org/10.1007/s000180050247
  3. Cech TR. Self-splicing of group I introns. Annu Rev Biochem. 1990;59:543-68. PMID:2197983 doi:http://dx.doi.org/10.1146/annurev.bi.59.070190.002551
  4. Roth A, Weinberg Z, Chen AG, Kim PB, Ames TD, Breaker RR. A widespread self-cleaving ribozyme class is revealed by bioinformatics. Nat Chem Biol. 2014 Jan;10(1):56-60. doi: 10.1038/nchembio.1386. Epub 2013 Nov, 17. PMID:24240507 doi:http://dx.doi.org/10.1038/nchembio.1386
  5. Weinberg Z, Kim PB, Chen TH, Li S, Harris KA, Lunse CE, Breaker RR. New classes of self-cleaving ribozymes revealed by comparative genomics analysis. Nat Chem Biol. 2015 Aug;11(8):606-10. doi: 10.1038/nchembio.1846. Epub 2015 Jul, 13. PMID:26167874 doi:http://dx.doi.org/10.1038/nchembio.1846

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Michal Harel, Alexander Berchansky, Wayne Decatur, Joel L. Sussman