Akt/PKB signaling pathway

The Akt signaling pathway or PI3K-Akt signaling pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are PI3K (phosphatidylinositol 3-kinase) and Akt (protein kinase B). See also Signal transduction. Activation Akt/PKB via Receptor tyrosine kinases/Ras Ras activation GTPase KRas Allosteric modulation of H-Ras GTPase

spinqualitylabelsall models PI3K (grey) complex with NISH2 P85α and wortmannin (PDB code 3hhm) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image