COVID-19 AlphaFold2 Models

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution. Model Confidence:   Very high (pLDDT > 90)   Confident (90 > pLDDT > 70)   Low (70 > pLDDT > 50)   Very low (pLDDT < 50) AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions below 50 pLDDT may be unstructured in isolation. As an example, to the right is an AlphaFold2 3D model of the SARS CoV-2 Protein N (UniProt ID: QHD43423) color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, i.e., model 5. At present, a number of 3D structures of proteins from the SARS CoV-2 virus have still not been determined experimentally. AlphaFold2 was used to predict 3D models for these proteins using the MIT ColabFold server. For each prediction, five 3D models were predicted, ranked from 1 to 5 (with 1 being the best). An example of such a predicted structure is the SARS CoV-2 Protein N (UniProt ID: QHD43423) color coded by the pLDDT scores. Views of these AlphaFold2 predictions can be seen on the Proteopedia pages: SARS-CoV-2 protein M - Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins. SARS-CoV-2 protein N - The primary function of the Nucleocapsid protein (N-protein) is to package the viral genome into a helical ribonucleoprotein (RNP) complex. SARS-CoV-2 protein ORF10 - It is currently unclear whether this region translates into a functional protein.]

spinqualitylabelsall models SARS-CoV-2 Protein N Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image