3d8b
Crystal structure of human fidgetin-like protein 1 in complex with ADPCrystal structure of human fidgetin-like protein 1 in complex with ADP
Structural highlights
Function[FIGL1_HUMAN] Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References
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OCACategories:
- Human
- Large Structures
- Andersson, J
- Arrowsmith, C H
- Berg, S Van Den
- Berglund, H
- Busam, R D
- Collins, R
- Dahlgren, L G
- Edwards, A M
- Flodin, S
- Flores, A
- Graslund, S
- Hammarstrom, M
- Johansson, A
- Johansson, I
- Kallas, A
- Karlberg, T
- Kotenyova, T
- Lehtio, L
- Moche, M
- Nilsson, M E
- Nordlund, P
- Nyman, T
- Olesen, K
- Persson, C
- Structural genomic
- Sagemark, J
- Schuler, H
- Thorsell, A G
- Tresaugues, L
- Welin, M
- Wikstrom, M
- Wisniewska, M
- Aaa+
- Adp
- Atp-binding
- Atpase
- Hydrolase
- Magnesium
- Metal-binding
- Nucleotide-binding
- Phosphoprotein
- Sgc