Interpreting ConSurf Results

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This page discusses how to decide if a ConSurf result is optimal for the questions you wish to ask about a protein. It assumes that you already have one or more completed ConSurf results. For background principles and instructions on how to get a ConSurf result, please see ConSurf/Index.

A ConSurf result depends crucially on the sequences included in the multiple sequence alignment (MSA). If you want to know which residues are important for the specific function of one protein, then the MSA should not include proteins with different functions. See Limiting ConSurf Analysis to Proteins of a Single Function.

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