Ca2+ signalling processes

Inositol 1,4,5-Trisphosphate Receptor Inositol 1,4,5-Trisphosphate Receptor binding protein is a ubiquitous protein involved in the Ca2+ signalling processes in a variety of organisms . The specific type of inositol 1,4,5-trisphosphate receptor (InsP3R) protein discussed here is the mouse type 1 InsP3R, also called InsP3R1. This polypeptide contains three major regions: the inositol 1,4,5-trisphosphate (InsP3) binding region, the central modulatory region, and the . The protein forms an L-shaped structure composed of two asymmetric domains perpendicular to each other. The N-terminal domain is made up of 12 β-strands and 2 single-turn helices, which come together to form a barrel. The C-terminal end is quite different, consisting of a bundle made of eight α-helices. The interface of the two domains is lined with basic residues and forms the for InsP3. The InsP3R protein does not belong to a superfamily of proteins. The receptor is thought to span the membrane 6 times, leaving the C-terminus in the cytoplasm. Calcium-dependent protein kinase Calcium/Calmodulin-dependent protein kinase Protein kinase C

spinqualitylabelsall models Mouse inositol triphosphate receptor ligand-binding core complex with its ligand inositol triphosphate (PDB entry 1n4k) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image