262d

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

A THREE-DIMENSIONAL MODEL OF THE REV BINDING ELEMENT OF HIV- 1 DERIVED FROM ANALYSES OF IN VITRO SELECTED VARIANTSA THREE-DIMENSIONAL MODEL OF THE REV BINDING ELEMENT OF HIV- 1 DERIVED FROM ANALYSES OF IN VITRO SELECTED VARIANTS

Structural highlights

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Resources:	FirstGlance, PDBsum, ProSAT

Publication Abstract from PubMed

Coordinated variations in the sequence of the Rev-binding element of HIV-1, identified by in vitro genetic selections, have been used as distance and conformational constraints for molecular modelling. Three-dimensional models of the wild-type Rev-binding element and several, evolved RNA ligands (aptamers) have been constructed. These models demonstrate that non-Watson-Crick pairings open the major groove allowing access of an alpha-helical peptide from Rev, and explain why some selected RNA sequences can bind Rev more tightly than others.

A three-dimensional model of the Rev-binding element of HIV-1 derived from analyses of aptamers.,Leclerc F, Cedergren R, Ellington AD Nat Struct Biol. 1994 May;1(5):293-300. PMID:7664035^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Leclerc F, Cedergren R, Ellington AD. A three-dimensional model of the Rev-binding element of HIV-1 derived from analyses of aptamers. Nat Struct Biol. 1994 May;1(5):293-300. PMID:7664035

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OCA

[1] Leclerc F, Cedergren R, Ellington AD. A three-dimensional model of the Rev-binding element of HIV-1 derived from analyses of aptamers. Nat Struct Biol. 1994 May;1(5):293-300. PMID:7664035

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