3hkv

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Human poly(ADP-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamideHuman poly(ADP-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide

Structural highlights

3hkv is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Gene:PARP10 (HUMAN)
Activity:NAD(+) ADP-ribosyltransferase, with EC number 2.4.2.30
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PAR10_HUMAN] May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. Yu M, Schreek S, Cerni C, Schamberger C, Lesniewicz K, Poreba E, Vervoorts J, Walsemann G, Grotzinger J, Kremmer E, Mehraein Y, Mertsching J, Kraft R, Austen M, Luscher-Firzlaff J, Luscher B. PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation. Oncogene. 2005 Mar 17;24(12):1982-93. PMID:15674325 doi:http://dx.doi.org/1208410
  2. Chou HY, Chou HT, Lee SC. CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10). J Biol Chem. 2006 Jun 2;281(22):15201-7. Epub 2006 Feb 2. PMID:16455663 doi:http://dx.doi.org/10.1074/jbc.M506745200

3hkv, resolution 2.10Å

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