1cd9
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2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR
OverviewOverview
Granulocyte colony-stimulating factor (GCSF) is the principal growth, factor regulating the maturation, proliferation and differentiation of the, precursor cells of neutrophilic granulocytes and is used to treat, neutropenia. GCSF is a member of the long-chain subtype of the class 1, cytokine superfamily, which includes growth hormone, erythropoietin, interleukin 6 and oncostatin M. Here we have determined the crystal, structure of GCSF complexed to the BN-BC domains, the principal, ligand-binding region of the GCSF receptor (GCSFR). The two receptor, domains form a complex in a 2:2 ratio with the ligand, with a, non-crystallographic pseudo-twofold axis through primarily the interdomain, region and secondarily the BC domain. This structural view of a gp130-type, receptor-ligand complex presents a new molecular basis for, cytokine-receptor recognition.
About this StructureAbout this Structure
1CD9 is a Protein complex structure of sequences from Homo sapiens and Mus musculus with NAG as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme., Aritomi M, Kunishima N, Okamoto T, Kuroki R, Ota Y, Morikawa K, Nature. 1999 Oct 14;401(6754):713-7. PMID:10537111
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