6z2h

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Citryl-CoA lyase module of human ATP citrate lyase in complex with (3S)-citryl-CoA.Citryl-CoA lyase module of human ATP citrate lyase in complex with (3S)-citryl-CoA.

Structural highlights

6z2h is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Gene:ACLY (HUMAN)
Activity:ATP citrate synthase, with EC number 2.3.3.8
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ACLY_HUMAN] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.[1]

References

  1. ↑ Lin R, Tao R, Gao X, Li T, Zhou X, Guan KL, Xiong Y, Lei QY. Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol Cell. 2013 Aug 22;51(4):506-18. doi: 10.1016/j.molcel.2013.07.002. Epub 2013 , Aug 8. PMID:23932781 doi:http://dx.doi.org/10.1016/j.molcel.2013.07.002

6z2h, resolution 1.80Å

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