1bmp

OverviewOverview

We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a, member of the transforming growth factor beta (TGF-beta) superfamily of, proteins and is able to induce new bone formation in vivo. Members of this, superfamily share sequence similarity in their C-terminal regions and are, implicated in embryonic development and adult tissue repair. Our crystal, structure makes possible the structural comparison between two members of, the TGF-beta superfamily. We find that although there is limited sequence, identity between OP-1 and TGF-beta 2, they share a common polypeptide, fold. These results establish a basis for proposing the OP-1/TGF-beta 2, fold as the primary structural motif for the TGF-beta superfamily as a, whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has, revealed striking differences that provide insights into how these growth, factors interact with their receptors.

About this StructureAbout this Structure

1BMP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily., Griffith DL, Keck PC, Sampath TK, Rueger DC, Carlson WD, Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):878-83. PMID:8570652

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