2iir

Acetate kinase from a hypothermophile Thermotoga maritimaAcetate kinase from a hypothermophile Thermotoga maritima

Structural highlights

2iir is a 10 chain structure with sequence from Atcc 43589. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1g99, 1tuu, 1tuy
Gene:	ack (ATCC 43589)
Activity:	Acetate kinase, with EC number 2.7.2.1
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ACKA_THEMA] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Phosphorylates propionate (54%) in addition to acetate (100%). Uses GTP (100%), ITP (163%), UTP (56%), and CTP (21%) as phosphoryl donors in addition to ATP (100%).^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Bock AK, Glasemacher J, Schmidt R, Schonheit P. Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima. J Bacteriol. 1999 Mar;181(6):1861-7. PMID:10074080

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OCA

[1] Bock AK, Glasemacher J, Schmidt R, Schonheit P. Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima. J Bacteriol. 1999 Mar;181(6):1861-7. PMID:10074080

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