1a15
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SDF-1ALPHA
OverviewOverview
Stromal cell-derived factor-1alpha (SDF-1alpha ) is a member of the, chemokine superfamily and functions as a growth factor and chemoattractant, through activation of CXCR4/LESTR/Fusin, a G protein-coupled receptor., This receptor also functions as a coreceptor for T-tropic, syncytium-inducing strains of HIV-1. SDF-1alpha antagonizes infectivity of, these strains by competing with gp120 for binding to the receptor. The, crystal structure of a variant SDF-1alpha ([N33A]SDF-1alpha ) prepared by, total chemical synthesis has been refined to 2.2-A resolution. Although, SDF-1alpha adopts a typical chemokine beta-beta-beta-alpha topology, the, packing of the alpha-helix against the beta-sheet is strikingly different., Comparison of SDF-1alpha with other chemokine structures confirms the, hypothesis that SDF-1alpha may be either an ancestral protein from which, all other chemokines evolved or the chemokine that is the least divergent, from a primordial chemokine. The structure of SDF-1alpha reveals a, positively charged surface ideal for binding to the negatively charged, extracellular loops of the CXCR4 HIV-1 coreceptor. This ionic, complementarity is likely to promote the interaction of the mobile, N-terminal segment of SDF-1alpha with interhelical sites of the receptor, resulting in a biological response.
DiseaseDisease
Known diseases associated with this structure: AIDS, resistance to OMIM:[600835]
About this StructureAbout this Structure
1A15 is a Single protein structure of sequence from [1] with SO4 as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor., Dealwis C, Fernandez EJ, Thompson DA, Simon RJ, Siani MA, Lolis E, Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6941-6. PMID:9618518
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