Calculating GDT TS

This page is under construction. Eric Martz 01:18, 5 March 2021 (UTC)

The Global Distance Test - Total Score (GDT_TS) is used to quantitate the similarity between a predicted protein structure, and a reference structure, which is typically an empirical model. When the two structures differ in detail, GDT_TS is better at detecting similarities in fold than is the Root Mean Square Deviation. Both tests compare the positions of only the alpha carbon atoms. Results of predictions submitted to the biannual CASP competitions are judged largely by GDT_TS.

Proteopedia pages using GDT_TS include Theoretical models and AlphaFold2 examples from CASP 14.

GDT_TS can be calculated with the free AS2TS Server provided by Adam Zemla. Below are detailed instructions.