2e8m

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Solution structure of the C-terminal SAM-domain of epidermal growth receptor pathway substrate 8Solution structure of the C-terminal SAM-domain of epidermal growth receptor pathway substrate 8

Structural highlights

2e8m is a 1 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:EPS8 (HUMAN)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

[EPS8_HUMAN] Upon binding to EGF receptor/EGFR enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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OCA