Regulatory protein E2

Regulatory protein E2 (RPE2) is a human papillomavirus (HPV) protein which is required for its replication. RPE2 targets the helicase Regulatory protein E1 (RPE1) to the origin of replication (ori). The HPV ori contains one RPE1 binding site and 2 RPE2 binding sites^[1]. RPE2 is found also in bovine papillomavirus (BPV).

Function

Disease

Relevance

Structural highlights

3D structures of regulatory protein E23D structures of regulatory protein E2

Updated on 27-January-2021

Domains: transactivation (TAD) 2-201; DNA-binding 286-365

1r8h, 2aye - RPE2 DBD - HPV6a
2ayb, 2ayg - RPE2 DBD + DNA
1r6k, 1r6n - RPE2 TAD + inhibitor - HPV11
1dto - RPE2 TAD - HPV16
2nnu - RPE2 TAD + BRD4 peptide
1by9, 2q79 - RPE2 DBD
3mi7 - RPE2 DBD (mutant)
1r8p, 1zzf - RPE2 DBD - NMR
1tue - RPE2 TAD + RPVE1 - HPV18
1qqh - RPE2 TAD
1f9f - RPE2 DBD
1jj4 - RPE2 DBD + DNA
1dhm - RPE2 DBD - HPV31 - NMR
1a7g - RPE2 DBD - HPV32
2jeu, 2jex - RPE2 TAD (mutant) - BPV1
1jjh, 6bus - RPE2 DBD
1dbd - RPE2 DBD - NMR
2bop - RPE2 DBD + DNA

ReferencesReferences

↑ Van Horn G, Sheikh S, Khan SA. Regulation of human papillomavirus type 1 replication by the viral E2 protein. Virology. 2001 Aug 15;287(1):214-24. doi: 10.1006/viro.2001.1037. PMID:11504556 doi:http://dx.doi.org/10.1006/viro.2001.1037

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Michal Harel, Alexander Berchansky

[1] Van Horn G, Sheikh S, Khan SA. Regulation of human papillomavirus type 1 replication by the viral E2 protein. Virology. 2001 Aug 15;287(1):214-24. doi: 10.1006/viro.2001.1037. PMID:11504556 doi:http://dx.doi.org/10.1006/viro.2001.1037

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