Nuclear receptor

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the nuclear receptors facts book [1]

StructureStructure

DBD (DNA Binding Domain)DBD (DNA Binding Domain)

LBD (Ligand Binding Domain)LBD (Ligand Binding Domain)


The structure of the LBD is strongly conserved throughout the familly of nuclear receptors. It is a globular domain, mainly alpha composed of arranged in a three layered sandwich, and a .

Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry 1ie8)

Drag the structure with the mouse to rotate
  1. Vincent Laudet, Hinrich Gronemeyer, "The nuclear receptor factsbook", Publisher Academic Press, 2002

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Schwarz Benjamin, Alexander Berchansky