1td5

Crystal Structure of the Ligand Binding Domain of E. coli IclR.Crystal Structure of the Ligand Binding Domain of E. coli IclR.

Structural highlights

1td5 is a 4 chain structure with sequence from "bacillus_coli"_migula_1895 "bacillus coli" migula 1895. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Related:	1t9l, 1tf1
Gene:	ICLR, B4018 ("Bacillus coli" Migula 1895)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

[ICLR_ECOLI] Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyruvate enhances promoter binding by stabilizing the tetrameric form.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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OCA

1td5

Crystal Structure of the Ligand Binding Domain of E. coli IclR.Crystal Structure of the Ligand Binding Domain of E. coli IclR.

Structural highlights

Function

Evolutionary Conservation

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1td5

Crystal Structure of the Ligand Binding Domain of E. coli IclR.Crystal Structure of the Ligand Binding Domain of E. coli IclR.

Structural highlights

Function

Evolutionary Conservation

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