1cwk
HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN
OverviewOverview
Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide a useful structural database for the analysis of protein-ligand interactions. The effect of small chemical differences on protein-ligand hydrogen-bonding, van der Waals interactions and water structure is presented.
About this StructureAbout this Structure
1CWK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A., Kallen J, Mikol V, Taylor P, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):435-49. PMID:9769216 Page seeded by OCA on Fri May 2 13:11:20 2008