NudT16

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IntroductionIntroduction

NudT16 is a hydrolase and belongs to the nucleoside diphosphate-linked moiety X (Nudix) family. This protein regulates levels of 53BP1 which is a protein that recruits other proteins to the site of a DNA breakage. NudT16 has also shown in vitro to remove ADP-ribosylation through its hydrolase activities.

StructureStructure

NudT16

NudT16 is a dimer

Crystal structure of HsNUDT16 in complex with diADPR (soaked)

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6W6Z

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5VY2 F36A mutant

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5JWI

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FunctionFunction

DiseaseDisease

RelevanceRelevance

Structural highlightsStructural highlights

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ReferencesReferences

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Tihitina Y Aytenfisu, Hannah Campbell, Sandra B. Gabelli, Michal Harel