2n71

NMR structure of CmPI-II, a serin protease inhibitor isolated from mollusk Cenchitis muricatusNMR structure of CmPI-II, a serin protease inhibitor isolated from mollusk Cenchitis muricatus

Structural highlights

2n71 is a 1 chain structure with sequence from Beaded periwinkle. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[IPK2_CENMR] Serine protease inhibitor. Strongly inhibits human neutrophil elastase and trypsin, also inhibits porcine pancreatic elastase and subtilisin A. Does not inhibit chymotrypsin, plasma kallikrein, pancreatic kallikrein, thrombin or papain.^[1] ^[2]

References

↑ Gonzalez Y, Tanaka AS, Hirata IY, del Rivero MA, Oliva ML, Araujo MS, Chavez MA. Purification and partial characterization of human neutrophil elastase inhibitors from the marine snail Cenchritis muricatus (Mollusca). Comp Biochem Physiol A Mol Integr Physiol. 2007 Apr;146(4):506-13. Epub 2006 Mar , 20. PMID:16546427 doi:http://dx.doi.org/10.1016/j.cbpa.2006.01.022
↑ Gonzalez Y, Pons T, Gil J, Besada V, Alonso-del-Rivero M, Tanaka AS, Araujo MS, Chavez MA. Characterization and comparative 3D modeling of CmPI-II, a novel 'non-classical' Kazal-type inhibitor from the marine snail Cenchritis muricatus (Mollusca). Biol Chem. 2007 Nov;388(11):1183-94. PMID:17976011 doi:http://dx.doi.org/10.1515/BC.2007.129

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OCA

[1] Gonzalez Y, Tanaka AS, Hirata IY, del Rivero MA, Oliva ML, Araujo MS, Chavez MA. Purification and partial characterization of human neutrophil elastase inhibitors from the marine snail Cenchritis muricatus (Mollusca). Comp Biochem Physiol A Mol Integr Physiol. 2007 Apr;146(4):506-13. Epub 2006 Mar , 20. PMID:16546427 doi:http://dx.doi.org/10.1016/j.cbpa.2006.01.022

[2] Gonzalez Y, Pons T, Gil J, Besada V, Alonso-del-Rivero M, Tanaka AS, Araujo MS, Chavez MA. Characterization and comparative 3D modeling of CmPI-II, a novel 'non-classical' Kazal-type inhibitor from the marine snail Cenchritis muricatus (Mollusca). Biol Chem. 2007 Nov;388(11):1183-94. PMID:17976011 doi:http://dx.doi.org/10.1515/BC.2007.129

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2n71

NMR structure of CmPI-II, a serin protease inhibitor isolated from mollusk Cenchitis muricatusNMR structure of CmPI-II, a serin protease inhibitor isolated from mollusk Cenchitis muricatus

Structural highlights

Function

References

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2n71

NMR structure of CmPI-II, a serin protease inhibitor isolated from mollusk Cenchitis muricatusNMR structure of CmPI-II, a serin protease inhibitor isolated from mollusk Cenchitis muricatus

Structural highlights

Function

References

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