CD81
FunctionCD81 is a cell-surface protein involved in a variety of biological responses like adhesion, morphology, activation, proliferation adn differentiation of of B- and T-cells[1]. CD81 belongs to the tetraspanin family - protein containing 4 transmembrane domains - which form microdomains in the cell surface with a variety of partner proteins. DiseaseRelevanceCD81 is widely expressed on the majority of tumor cells. Antibodies that target CD81 are a novel treatment against B-cell lymphoma[2]. CD81-defficient mice are impaired in their ability to suppress the anti-tumor immune response. Structural highlights |
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3D structures of CD813D structures of CD81
5tcx - hCD81 (mutant) - human
1g8q, 1iv5, 5m3t, 5m3d, 5m4r, 5m33, 5m2c, 3x0e, 3x0f - hCD81 extracellular domain 113-202
6ejm, 6ek2, 6ejg, 5dfw - hCD81 extracellular domain + Scfv
5dfv - hCD81 extracellular domain + antibody
3k0g - CD81 extracellular domain - green monkey
6u9s - CD81 extracellular domain + antibody - mouse
ReferencesReferences
- ↑ Levy S, Todd SC, Maecker HT. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu Rev Immunol. 1998;16:89-109. doi: 10.1146/annurev.immunol.16.1.89. PMID:9597125 doi:http://dx.doi.org/10.1146/annurev.immunol.16.1.89
- ↑ Vences-Catalan F, Kuo CC, Rajapaksa R, Duault C, Andor N, Czerwinski DK, Levy R, Levy S. CD81 is a novel immunotherapeutic target for B cell lymphoma. J Exp Med. 2019 Jul 1;216(7):1497-1508. doi: 10.1084/jem.20190186. Epub 2019 May , 23. PMID:31123084 doi:http://dx.doi.org/10.1084/jem.20190186