5f8t

The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2

Structural highlights

5f8t is a 2 chain structure with sequence from Human. This structure supersedes the now removed PDB entry 4zj5. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	4zj4, 4zj6
Gene:	KLKB1, KLK3 (HUMAN)
Activity:	Plasma kallikrein, with EC number 3.4.21.34
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[KLKB1_HUMAN] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.

Function

[KLKB1_HUMAN] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

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