6t7x

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Crystal structure of PCNA from P. abyssiCrystal structure of PCNA from P. abyssi

Structural highlights

6t7x is a 1 chain structure with sequence from Pyrab. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:pcn, PYRAB13790, PAB1465 (PYRAB)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PCNA_PYRAB] Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Regulates activity of NucS endonuclease and prevents non-specific cleavage.[HAMAP-Rule:MF_00317][1]

References

  1. ↑ Creze C, Ligabue A, Laurent S, Lestini R, Laptenok SP, Khun J, Vos MH, Czjzek M, Myllykallio H, Flament D. Modulation of the Pyrococcus abyssi NucS endonuclease activity by replication clamp at functional and structural levels. J Biol Chem. 2012 May 4;287(19):15648-60. doi: 10.1074/jbc.M112.346361. Epub 2012, Mar 19. PMID:22431731 doi:http://dx.doi.org/10.1074/jbc.M112.346361

6t7x, resolution 2.30Å

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