1a0b
HISTIDINE-CONTAINING PHOSPHOTRANSFER DOMAIN OF ARCB FROM ESCHERICHIA COLI
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OverviewOverview
The histidine-containing phosphotransfer (HPt) domain is a novel protein, module with an active histidine residue that mediates phosphotransfer, reactions in the two-component signaling systems. A multistep phosphorelay, involving the HPt domain has been suggested for these signaling pathways., The crystal structure of the HPt domain of the anaerobic sensor kinase, ArcB has been determined at 2.06 A resolution. The domain consists of six, alpha helices containing a four-helix bundle-folding. The pattern of, sequence similarity of the HPt domains of ArcB and components in other, signaling systems can be interpreted in light of the three-dimensional, structure and supports the conclusion that the HPt domains have a common, structural motif both in prokaryotes and eukaryotes.
About this StructureAbout this Structure
1A0B is a [Single protein] structure of sequence from [Escherichia coli] with ZN as [ligand]. Full crystallographic information is available from [OCA].
ReferenceReference
Insights into multistep phosphorelay from the crystal structure of the C-terminal HPt domain of ArcB., Kato M, Mizuno T, Shimizu T, Hakoshima T, Cell. 1997 Mar 7;88(5):717-23. PMID:9054511
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