6te6

Crystal structure of Dot1L in complex with an inhibitor (compound 3).Crystal structure of Dot1L in complex with an inhibitor (compound 3).

Structural highlights

6te6 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Activity:	Histone-lysine N-methyltransferase, with EC number 2.1.1.43
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.

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6te6

Crystal structure of Dot1L in complex with an inhibitor (compound 3).Crystal structure of Dot1L in complex with an inhibitor (compound 3).

Structural highlights

Function

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6te6

Crystal structure of Dot1L in complex with an inhibitor (compound 3).Crystal structure of Dot1L in complex with an inhibitor (compound 3).

Structural highlights

Function

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