3bgp
Human Pim-1 complexed with a benzoisoxazole inhibitor VX1
OverviewOverview
To supplement the hits from a high throughput screen, docking was performed against Pim-1 kinase. Glide docking was augmented with a filter to require traditional or aromatic CH..O hydrogen bonds to the kinase hinge. Four diverse actives, of 96 molecules assayed, had K(i) values between 0.091 and 4.5 microM. This gives a 14-fold enrichment over the earlier HTS run, and the two crystal structures solved confirmed the binding modes predicted by docking.
About this StructureAbout this Structure
3BGP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase., Pierce AC, Jacobs M, Stuver-Moody C, J Med Chem. 2008 Mar 27;51(6):1972-5. Epub 2008 Feb 22. PMID:18290603 Page seeded by OCA on Wed Apr 30 13:38:41 2008
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OCA- Pages with broken file links
- Homo sapiens
- Non-specific serine/threonine protein kinase
- Single protein
- Jacobs, M D.
- Alternative initiation
- Atp-binding
- Cytoplasm
- Kinase inhibitor phosphorylation
- Manganese
- Membrane
- Metal-binding
- Nucleotide-binding
- Nucleus
- Phosphoprotein
- Proto-oncogene
- Serine/threonine-protein kinase
- Transferase