Telomerase-associated protein

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Function

The telomerase-associated proteins (TAP) are components of the ribonucleoprotein complex responsible for telomerase activity and catalyze the addition of new telomeres on the chromosome ends[1].

Structural highlights

The [2].


Telomerase-associated protein p65 C-terminal complex with RNA and K+ ion (purple) (PDB code 4erd)

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3D structures of telomerase-associated protein3D structures of telomerase-associated protein

Updated on 19-September-2019

5dof, 5dfm - TtTAP 19 - Tetrahymena thermophyla
5doi - TtTAP 19 + TAP p45
5dok - TtTAP p45
5dfn - TtTAP p45 C-terminal
2lsl - TtTAP p65 C-terminal - NMR
4erd - TtTAP p65 C-terminal + RNA
4eyt - TtTAP p65 C-terminal
3u4v, 3u4z, 3u50 - TtTAP 82 TEB1 domain
6d6v - TtTAP p50+p65+p82 + telomerase reverse transcriptase + telomerse TEB2 subunit + RNA + DNA - Cryo EM

ReferencesReferences

  1. ↑ Lewis KA, Wuttke DS. Telomerase and telomere-associated proteins: structural insights into mechanism and evolution. Structure. 2012 Jan 11;20(1):28-39. doi: 10.1016/j.str.2011.10.017. PMID:22244753 doi:http://dx.doi.org/10.1016/j.str.2011.10.017
  2. ↑ Singh M, Wang Z, Koo BK, Patel A, Cascio D, Collins K, Feigon J. Structural Basis for Telomerase RNA Recognition and RNP Assembly by the Holoenzyme La Family Protein p65. Mol Cell. 2012 Jun 14. PMID:22705372 doi:10.1016/j.molcel.2012.05.018

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Michal Harel, Joel L. Sussman, Alexander Berchansky
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