R configuration S configuration

Carbon (gray) with four substituents (labeled by priority 1-4) shows an R-configuration because when substituent 4 is in the back, substituents 1 - 3 run clockwise.

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Carbon (gray) with four substituents (labeled by priority 1-4) shows an S-configuration because when substituent 4 is in the back, substituents 1 - 3 run counterclockwise.

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Karsten Theis