6edw

Crystal structure of Mycobacterium tuberculosis ICL2 in the apo formCrystal structure of Mycobacterium tuberculosis ICL2 in the apo form

Structural highlights

6edw is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
NonStd Res:
Related:	6edz, 6ee1
Activity:	Isocitrate lyase, with EC number 4.1.3.1
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ACEA2_MYCTO] Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.^[1] ^[2] ^[3]

References

↑ Honer Zu Bentrup K, Miczak A, Swenson DL, Russell DG. Characterization of activity and expression of isocitrate lyase in Mycobacterium avium and Mycobacterium tuberculosis. J Bacteriol. 1999 Dec;181(23):7161-7. PMID:10572116
↑ Munoz-Elias EJ, McKinney JD. Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence. Nat Med. 2005 Jun;11(6):638-44. doi: 10.1038/nm1252. Epub 2005 May 15. PMID:15895072 doi:http://dx.doi.org/10.1038/nm1252
↑ Gould TA, van de Langemheen H, Munoz-Elias EJ, McKinney JD, Sacchettini JC. Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis. Mol Microbiol. 2006 Aug;61(4):940-7. doi: 10.1111/j.1365-2958.2006.05297.x. PMID:16879647 doi:http://dx.doi.org/10.1111/j.1365-2958.2006.05297.x

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Honer Zu Bentrup K, Miczak A, Swenson DL, Russell DG. Characterization of activity and expression of isocitrate lyase in Mycobacterium avium and Mycobacterium tuberculosis. J Bacteriol. 1999 Dec;181(23):7161-7. PMID:10572116

[2] Munoz-Elias EJ, McKinney JD. Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence. Nat Med. 2005 Jun;11(6):638-44. doi: 10.1038/nm1252. Epub 2005 May 15. PMID:15895072 doi:http://dx.doi.org/10.1038/nm1252

[3] Gould TA, van de Langemheen H, Munoz-Elias EJ, McKinney JD, Sacchettini JC. Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis. Mol Microbiol. 2006 Aug;61(4):940-7. doi: 10.1111/j.1365-2958.2006.05297.x. PMID:16879647 doi:http://dx.doi.org/10.1111/j.1365-2958.2006.05297.x

[1]

[2]

[3]

6edw

Crystal structure of Mycobacterium tuberculosis ICL2 in the apo formCrystal structure of Mycobacterium tuberculosis ICL2 in the apo form

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

6edw

Crystal structure of Mycobacterium tuberculosis ICL2 in the apo formCrystal structure of Mycobacterium tuberculosis ICL2 in the apo form

Structural highlights

Function

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Search