6k5l

The crystal structure of isocitrate dehydrogenase kinase/phosphatase wtih two Mn2+ from E. coliThe crystal structure of isocitrate dehydrogenase kinase/phosphatase wtih two Mn2+ from E. coli

Structural highlights

6k5l is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[A0A1Z3UWE5_ECOLX] Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.[HAMAP-Rule:MF_00747][SAAS:SAAS00963147]

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6k5l

The crystal structure of isocitrate dehydrogenase kinase/phosphatase wtih two Mn2+ from E. coliThe crystal structure of isocitrate dehydrogenase kinase/phosphatase wtih two Mn2+ from E. coli

Structural highlights

Function

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6k5l

The crystal structure of isocitrate dehydrogenase kinase/phosphatase wtih two Mn2+ from E. coliThe crystal structure of isocitrate dehydrogenase kinase/phosphatase wtih two Mn2+ from E. coli

Structural highlights

Function

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