Murin CXCL13 solution structure featuring a folded N-terminal domainMurin CXCL13 solution structure featuring a folded N-terminal domain

Structural highlights

5izb is a 1 chain structure with sequence from Lk3 transgenic mice. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:Cxcl13, Blc, Scyb13 (LK3 transgenic mice)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CXL13_MOUSE] Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.

See Also

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