Calcium/Calmodulin-dependent protein kinase

Function Ca2+/Calmodulin dependent protein kinase (CaMK) are mammalian calmodulin-dependent calcium-dependent protein kinases activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr. CaMKI is a specialized CaM kinase. CaMKII is multifunctional kinase. CaMKIII phosphorylates eukaryotic elongation factor 2. CASK is a membrane associated CaMK. DAPK is a death-associated CaMK which protects cells from some programmed cell death. For details see Calcium-dependent protein kinase. Structural highlights CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. The activity of human CamKII is regulated by autophosphorylation of and Thr 305 (T305 is not in the pdb file). 3D Structures of Calcium/calmodulin dependent protein kinase Calcium/calmodulin dependent protein kinase 3D structures

spinqualitylabelsall models Human CamKII subunit α kinase domain complex with indirubin (PDB code 2vz6) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Calcium/calmodulin dependent protein kinase3D Structures of Calcium/calmodulin dependent protein kinase

Updated on 18-April-2019

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• CaMKI – specialized CaM kinase
  • 1a06 – rCaMK - rat
    
  • 4fgb – hCaMKI - human
    
  • 4fg9, 4fg8, 4fg7 – hCaMKI + ATP
    
  • 2jam - hCaMKI kinase domain +peptides
    
• CASK – membrane-associated CaMK
  • 3mfr – hCASK CBD
    
  • 3mfs – hCASK+AMPPNP
    
  • 3mft – hCASK+Mn
    
  • 3c0g – hCASK kinase domain
    
  • 3c0h - hCASK kinase domain+AMPPNP
    
  • 3c0i - hCASK kinase domain+AMP
    
  • 3tac – hCASK kinase domain + liprin-α-2
    
  • 3mfu - hCASK+AMPPNP+Mn
    
• DAPK – death-associated CaMK
  • 2x0g – hDAPK RD+AD+CaM
    
  • 2cke – hDAPK+inhibitor
    
• CaMKII – multifunctional CaM kinase
  • 3kk9, 3kk8 - hCaMKII kinase domain
    
  • 3soa - hCaMKII (mutant)
    
  • 3kl8 - hCaMKII (mutant) + inhibitor
    
  • 5ig3 - hCaMKII α chain
    
  • 5hu3, 5h9b, 5fg8 - hCaMKII α chain + potassium channel protein EAG
    
  • 2vz6 - hCaMKII α + indirubin-E804
    
  • 6of8 - hCaMKII α chain HUB domain (mutant)
    
  • 3bhh - hCaMKII β
    
  • 2zv2 – hCaMKII β +STO-609
    
  • 6hcs - hCaMKII β chain + calmodulin
    
  • 2v7o - hCaMKII γ
    
  • 2ux0 - hCaMKII γ (mutant)
    
  • 2wel - hCaMKII δ + CaM
    
  • 2w2c - hCaMKII δ oligomerization domain
    
  • 2vn9 - hCaMKII δ
    
  • 2jc6 - hCaMKII δ
    
  • 6ayw, 5vlo - hCaMKII δ chain + inhibitor
    
  • 1hkx - mCaMKII α - mouse
    
  • 6bab - mCaMKII δ chain + inhibitor
    
  • 5u6y - rCaMKII α chain
    
  • 3gp2 – cCaMKII δ + CaM – chicken
    
• CaMKIV
  • 2w4o – hCaMKIV+inhibitor
    

ReferencesReferences

See Calcium-dependent protein kinase