6ccf

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Crystal Structure of the Human CAMKK1A in complex with HesperadinCrystal Structure of the Human CAMKK1A in complex with Hesperadin

Structural highlights

6ccf is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Gene:CAMKK1, CAMKKA (HUMAN)
Activity:Calcium/calmodulin-dependent protein kinase, with EC number 2.7.11.17
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[KKCC1_HUMAN] Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.[1]

See Also

References

  1. ↑ Ishikawa Y, Tokumitsu H, Inuzuka H, Murata-Hori M, Hosoya H, Kobayashi R. Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. FEBS Lett. 2003 Aug 28;550(1-3):57-63. PMID:12935886

6ccf, resolution 2.10Å

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