1rfe

Crystal structure of conserved hypothetical protein Rv2991 from Mycobacterium tuberculosisCrystal structure of conserved hypothetical protein Rv2991 from Mycobacterium tuberculosis

Structural highlights 1rfe is a 1 chain structure with sequence from Myctu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. NonStd Res: , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The crystal structure of the conserved hypothetical protein Rv2991 from Mycobacterium tuberculosis has been solved by SAD using seleno-methionine substituted protein. The dimeric biological assembly and the sequence and fold conservation are typical of F420 cofactor binding enzymes. Despite Rv2991 still being of unknown function, sequence and structural comparison with similar proteins enable a role to be proposed for its C-terminal stretch of residues in recognizing and orienting the substrate. In addition, the C-terminus is involved in both protein folding and determining the size of the active site cavity. The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F420 binding protein with unknown function.,Benini S, Haouz A, Proux F, Alzari P, Wilson K J Struct Biol. 2019 Mar 16. pii: S1047-8477(19)30051-6. doi:, 10.1016/j.jsb.2019.03.006. PMID:30890426 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

spinqualitylabelsall models 1rfe, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image