6fvi

ASH / PapD-like domain of human CEP192 (PapD-like domain 7)ASH / PapD-like domain of human CEP192 (PapD-like domain 7)

Structural highlights

6fvi is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CE192_HUMAN] Required for mitotic centrosome maturation and bipolar spindle assembly (PubMed:25042804, PubMed:17980596, PubMed:18207742). Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication (PubMed:25042804, PubMed:17980596, PubMed:18207742). Centrosome-specific activating scaffold for AURKA and PLK1 (PubMed:25042804).^[1] ^[2] ^[3]

References

↑ Gomez-Ferreria MA, Rath U, Buster DW, Chanda SK, Caldwell JS, Rines DR, Sharp DJ. Human Cep192 is required for mitotic centrosome and spindle assembly. Curr Biol. 2007 Nov 20;17(22):1960-6. doi: 10.1016/j.cub.2007.10.019. Epub 2007, Nov 1. PMID:17980596 doi:http://dx.doi.org/10.1016/j.cub.2007.10.019
↑ Zhu F, Lawo S, Bird A, Pinchev D, Ralph A, Richter C, Muller-Reichert T, Kittler R, Hyman AA, Pelletier L. The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis. Curr Biol. 2008 Jan 22;18(2):136-41. doi: 10.1016/j.cub.2007.12.055. PMID:18207742 doi:http://dx.doi.org/10.1016/j.cub.2007.12.055
↑ Joukov V, Walter JC, De Nicolo A. The Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly. Mol Cell. 2014 Aug 21;55(4):578-91. doi: 10.1016/j.molcel.2014.06.016. Epub 2014 , Jul 17. PMID:25042804 doi:http://dx.doi.org/10.1016/j.molcel.2014.06.016

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OCA

[1] Gomez-Ferreria MA, Rath U, Buster DW, Chanda SK, Caldwell JS, Rines DR, Sharp DJ. Human Cep192 is required for mitotic centrosome and spindle assembly. Curr Biol. 2007 Nov 20;17(22):1960-6. doi: 10.1016/j.cub.2007.10.019. Epub 2007, Nov 1. PMID:17980596 doi:http://dx.doi.org/10.1016/j.cub.2007.10.019

[2] Zhu F, Lawo S, Bird A, Pinchev D, Ralph A, Richter C, Muller-Reichert T, Kittler R, Hyman AA, Pelletier L. The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis. Curr Biol. 2008 Jan 22;18(2):136-41. doi: 10.1016/j.cub.2007.12.055. PMID:18207742 doi:http://dx.doi.org/10.1016/j.cub.2007.12.055

[3] Joukov V, Walter JC, De Nicolo A. The Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly. Mol Cell. 2014 Aug 21;55(4):578-91. doi: 10.1016/j.molcel.2014.06.016. Epub 2014 , Jul 17. PMID:25042804 doi:http://dx.doi.org/10.1016/j.molcel.2014.06.016

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