Ephrin

Function Ephrins (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation . Disease Eph-A5 is implicated in spinal cord injury. Eph-A1 is implicated in myocardial injury and renal reperfusion injury. Structural highlights (PDB code 3mx0).

spinqualitylabelsall models Structure of glycosylated human ephrin-A5 receptor-binding domain (green) complex with ephrin type A receptor 2 (cyan) (PDB code 3mx0). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of ephrin3D structures of ephrin

Updated on 11-March-2019

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• Ephrin-A5
  • 1shx – mEph receptor-binding domain – mouse
    
  • 1shw – mEph residues 88-225 + Eph type B receptor 2
    
  • 2x11, 3mx0 – hEph receptor-binding domain + Eph type A receptor 2 - human
    
  • 4bk5, 4bka, 4m4r – hEph receptor-binding domain + Eph type A receptor 4
    
  • 4l0p – hEph receptor-binding domain + Eph type A receptor 3
    
• Ephrin-B2
  • 2i85 – hEph residues 1-142 – NMR
    
  • 1iko – mEph ectodomain
    
  • 1kgy – mEph receptor-binding domain + Eph type B receptor 2
    
  • 2hle – mEph receptor-binding domain + Eph type B receptor 4
    
  • 2wo2, 3gxu – hEph receptor-binding domain + Eph type A receptor 4
    
  • 4uf7 – hEph receptor-binding domain + glycoprotein
    
  • 2vsk, 2vsm – hEph receptor-binding domain + virus hemagglutinin neuraminidase
    
• Ephrin-B3
  • 3d12 – mEph receptor-binding domain + virus hemagglutinin neuraminidase
    
  • 4bkf – hEph receptor-binding domain + Eph type A receptor 4
    
• Ephrin-A1
  • 3hei, 3mbw, 3czu – hEph receptor-binding domain + Eph type A receptor 2
    
  • 3fl7 – hEph ectodomain
    
• Ephrin-A2
  • 2wo3 – hEph receptor-binding domain + Eph type A receptor 4
    
• Ephrin-A3
  • 3dzq – hEph kinase domain + inhibitor