14-3-3 protein

Function

14-3-3 proteins (PRS) are conserved regulatory proteins which bind to a multitude of signaling proteins like kinases phosphatases and transmembrane receptors. The name 14-3-3 derives from their elution pattern via chromatography.^[1]

Disease

Elevated levels of PRS are found in patients with Creutzfeld-Jakob disease (CJD). PRS are associated with Parkinson Disease (PD) and with Alzheimer Disease (AD) based on their localization and their binding to PD and AD-associated proteins.

Relevance

PRS are tested as biomarkers for CJD, PD and AD.

Structural highlights

PRS are homo- and heterodimers containing . (3 helices of chain A are in red and 3 helices of chain B are in magenta). .

3D structures of 14-3-3 protein

14-3-3 protein 3D structures

Structure of human 14-3-3 protein ζ with phosphopeptide (yellow) (PDB code 1qja).

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Benzinger A, Popowicz GM, Joy JK, Majumdar S, Holak TA, Hermeking H. The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization. Cell Res. 2005 Apr;15(4):219-27. PMID:15857576 doi:10.1038/sj.cr.7290290

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Benzinger A, Popowicz GM, Joy JK, Majumdar S, Holak TA, Hermeking H. The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization. Cell Res. 2005 Apr;15(4):219-27. PMID:15857576 doi:10.1038/sj.cr.7290290

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