Arsenate reductase

Function Arsenate reductase (AsR) catalyzes the conversion of arsenate (As V) and glutaredoxin to arsenite (As III) and glutaredoxin disulfide. Relevance AsR is part of the arsenic detoxification pathway. Structural highlights The AsR active site contains a . (PDB entry 1j9b).

spinqualitylabelsall models Structure of arsenate reductase complex with arsenate, thiarsahydroxy-cysteine, sulfate and Cs+ ion (dark purple) (PDB entry 1j9b) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of arsenate reductase3D structures of arsenate reductase

Updated on 07-January-2019

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• Arsenate reductase
  • 1jf8, 1ljl – SaAsR – Staphylococcus aureus
    
  • 1jfv, 1lk0, 1rxi, 2cd7, 2fxi – SaAsR (mutant)
    
  • 1jl3 – BsAsR – Bacillus subtilis
    
  • 1z2d, 1z2e – BsAsR - NMR
    
  • 1i9d – EcAsR – Escherichia coli
    
  • 1s3c, 1s3d, 1sd8, 1sd9, 1sk2 – EcAsR (mutant)
    
  • 2l17, 2l18, 2myn, 2myp – SyAsR – Synechocystis - NMR
    
  • 2l19, 2myt, 2myu – SyAsR (mutant) - NMR
    
  • 1y1l – AsR – Archaeoglobus fulgidus
    
  • 3f0i – AsR – Vibrio cholerae
    
  • 2kok, 2mu0 – AsR – Brucella abortus
    
  • 3rh0, 3t38 – AsR – Corynebacterium glutamicum
    
• Arsenate reductase complexes
  • 1jzw – EcAsR + arsonocysteine
    
  • 1sk1 – EcAsR (mutant) + arsonocysteine
    
  • 1sjz, 1sk0 – EcAsR (mutant) + arsonocysteine + AsO3
    
  • 1j9b – EcAsR + AsO3 + thiarsahydroxy-cysteine
    
  • 1lju – SaAsR (mutant) + arsonocysteine
    
  • 1rxe – SaAsR (mutant) + mercapto-nitrobenzoate
    
  • 2ipa – BsAsR (mutant) + thioredoxin (mutant)