Ras-related protein Rab

Function Ras-related protein Rab-11A belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways and with pathways regulating protein traffic. Rab cycles between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors responsible for vesicle formation, movement, tethering and fusion. Disease Rab-11A, Rab-11B and Rab-25 are associated with Alzheimer disease, Huntington disease, type 2 diabetes and cancer. Structural highlights Rab-11A undergoes a conformation change of two switch regions between its inactive GDP-bound structure and its active GTP-bound structure. GDP forms numerous interactions at the active site located at the surface of the protein.

spinqualitylabelsall models Human Rab-11A complex with GDP, phosphate and Mg+2 ion (green) (PDB code 1oix) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of Ras-related protein Rab3D structures of Ras-related protein Rab

Updated on 19-December-2018

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• Rab-11A complex with nucleotide
  • 1oiv – hRab-11A + GDP - human
    
  • 1oix – hRab-11A (mutant) + GDP
    
  • 5ez5 – hRab-11A (mutant) + GTP
    
  • 1yzk – hRab-11A + GppNHp
    
  • 1oiw – hRab-11A (mutant) + GTPγS
    
  • 3bfk – Rab-11A + GDP – Plasmodium falciparum
    
  • 5xr4 – AtRab-11A + GDP – Arabidopsis thaliana
    
  • 5xr7 – AtRab-11A (mutant) + GTP
    
  • 5xr6 – AtRab-11A + GppNHp
    
• Rab-11A other complexes
  • 4c4p – hRab-11A + Rab11 family-interacting protein 2
    
  • 2gzd, 2gzh – hRab-11A (mutant) + Rab11 family-interacting protein 2
    
  • 2hv8, 2d7c – hRab-11A (mutant) + Rab11 family-interacting protein 3
    
  • 4d0m – hRab-11A (mutant) + Rab11 family-interacting protein 3 + PI4KB
    
  • 4uj5 – hRab-11A (mutant) + Rab-3A interacting protein 3
    
  • 4uj3, 4uj4 – hRab-11A (mutant) + Rab11 family-interacting protein 3 + Rab-3A interacting protein 3
    
  • 5jcz – hRab-11A + unconventional myosin-Va
    
  • 4lwz, 4lx0 – hRab-11A + unconventional myosin-Vb
    
  • 6djl – hRab-11A (mutant) + SH3 domain-binding protein 5
    
  • 5fbl, 5fbq, 5fbr, 5fbv, 5fbw – hRab-11A + PI4KB + inhibitor
    
  • 5c46 – hRab-11A (mutant) + PI4KB + GDPγS
    
  • 5c4g, 5euq, 4d0l – hRab-11A (mutant) + PI4KB + GDPγS + inhibitor
    
• Rab-14
  • 4d0g – hRab-14 (mutant) + Rab11 family-interacting protein 1
    
• Rab-25
  • 3tso – hRab-25 + Rab11 family-interacting protein 2