6f4u

Crystal structure of reactive loop cleaved kallistatin at 1.9 angstrom resolutionCrystal structure of reactive loop cleaved kallistatin at 1.9 angstrom resolution

Structural highlights

6f4u is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[KAIN_HUMAN] Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.^[1]

References

↑ Chai KX, Chen LM, Chao J, Chao L. Kallistatin: a novel human serine proteinase inhibitor. Molecular cloning, tissue distribution, and expression in Escherichia coli. J Biol Chem. 1993 Nov 15;268(32):24498-505. PMID:8227002

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OCA

[1] Chai KX, Chen LM, Chao J, Chao L. Kallistatin: a novel human serine proteinase inhibitor. Molecular cloning, tissue distribution, and expression in Escherichia coli. J Biol Chem. 1993 Nov 15;268(32):24498-505. PMID:8227002

[1]

6f4u

Crystal structure of reactive loop cleaved kallistatin at 1.9 angstrom resolutionCrystal structure of reactive loop cleaved kallistatin at 1.9 angstrom resolution

Structural highlights

Function

References

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6f4u

Crystal structure of reactive loop cleaved kallistatin at 1.9 angstrom resolutionCrystal structure of reactive loop cleaved kallistatin at 1.9 angstrom resolution

Structural highlights

Function

References

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