3edh

Crystal structure of bone morphogenetic protein 1 protease domain in complex with partially bound DMSOCrystal structure of bone morphogenetic protein 1 protease domain in complex with partially bound DMSO

Structural highlights 3edh is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: , , Related: 3edg, 3edi, 1dle Gene: BMP1, PCOLC (HUMAN) Activity: Procollagen C-endopeptidase, with EC number 3.4.24.19 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [BMP1_HUMAN] Defects in BMP1 are the cause of osteogenesis imperfecta 13 (OI13) [MIM:614856]. An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility, low bone mass, and recurrent fractures. OI13 is characterized by normal teeth, faint blue sclerae, severe growth deficiency, borderline osteoporosis, severe bone deformity, and recurrent fractures affecting both upper and lower limbs. Function [BMP1_HUMAN] Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Bone morphogenetic protein

spinqualitylabelsall models 3edh, resolution 1.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image