6bop

Crystal structure of 2-methylcitrate synthase from Aspergillus fumigatusCrystal structure of 2-methylcitrate synthase from Aspergillus fumigatus

Structural highlights

6bop is a 4 chain structure with sequence from Aspfm. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	mcsA, cit1 (ASPFM)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PRPC_ASPFM] Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate. May play a role in virulence.^[1]

References

↑ Maerker C, Rohde M, Brakhage AA, Brock M. Methylcitrate synthase from Aspergillus fumigatus. Propionyl-CoA affects polyketide synthesis, growth and morphology of conidia. FEBS J. 2005 Jul;272(14):3615-30. doi: 10.1111/j.1742-4658.2005.04784.x. PMID:16008561 doi:http://dx.doi.org/10.1111/j.1742-4658.2005.04784.x

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OCA

[1] Maerker C, Rohde M, Brakhage AA, Brock M. Methylcitrate synthase from Aspergillus fumigatus. Propionyl-CoA affects polyketide synthesis, growth and morphology of conidia. FEBS J. 2005 Jul;272(14):3615-30. doi: 10.1111/j.1742-4658.2005.04784.x. PMID:16008561 doi:http://dx.doi.org/10.1111/j.1742-4658.2005.04784.x

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